Chair and Department of Pharmacology and Pharmacodynamics
- ul. Chodźki 4a (Collegium Pharmaceuticum)
- +48 81448 7250
+48 81448 7252
- 48814 4872
The Department of Pharmacodynamics was established in 1947 within the structure of the Department of Pharmaceutical Chemistry (the Faculty of Pharmacy at the Medical University of Lublin). The first Head of the Department was prof. Kazimierz Kalinowski. In 1957 the Department was located at a new building in 4 Staszica St., after determined efforts of prof. Józef Jeske. Since January 2011 the Department has been located in a new building of the Faculty of Pharmacy in 4a Chodźki St.
First research articles of the Department concerned pharmacodynamics study on the properties of new substances and the effect of ATP on carbohydrate hypoglycemic animals (appeared in print in 1960). Other works were related to the pharmacology of antibiotics. It should be emphasized that in this period has been established scientific cooperation with the Union of Pharmaceutical Industry "Polfa". The result of this collaboration was a description of a pharmacological documentation for certain drugs. In the years 1968-1973 in the Department of Pharmacology the basic themes were focused on the central nervous system and the cardiovascular system. Most work in this period was carried out in cooperation with the Institute of Pharmacology, Polish Academy of Sciences (Cracow). Since 1976, the Department has expanded the theme of the central effects of narcotic analgesics. In the eighties and nineties of XX century, several employees at the Department received foreign scholarships: Italy (prof. Sylwia Fidecka and Alicja Kruszewska PhD), USA (Ewa Tamborska, PhD), Sweden (prof. Jolanta Kotlińska) and France (prof. Grażyna Biała).
In the Department there are currently 14 employees including:
- academics positions: the Head of the Department (professor), 2 professors (one of them is an emeritus professor), 7 assistant professors, 2 assistants,
- 2 technicians.
There are also 4 doctoral students:
- Marta Marszałek-Grabska, MSc.
- Karolina Pękała, MSc.
- Małgorzata Łupina, MSc.
- Joanna Filarowska, MSc.
Department of Pharmacology and Pharmacodynamics provides classes on PHARMACOLOGY for 4th and 5th year pharmacy students; cosmetology students and medical analytics students. Moreover, we teach pharmacology in English students of dentistry (II Faculty of Medicine with English Language Division). Every year 14-16 master theses are done in our Department for students of the 5th year of pharmacy or cosmetology. Main teaching goal of the Department is to introduce students to basic and clinical pharmacology. Our students participate in lectures and seminars about pharmacokinetic and pharmacodynamics properties of drugs. During seminars they prepare their own presentations on selected subjects. Seminars are dynamic forms of teaching when students can active acquire pharmacological knowledge.
Current research subjects:
- The examination of acute and chronic effects of mephedrone, interaction between mephedrone and other psychoactive substances, establishing mechanisms involved in their action in different time-points.
- The influence of the chemical structure of coumarins derivatives on their central effects showed in behavioral and biochemical studies.
- The behavioral and biochemical involvement of endocannabinoid system in the memory-, emotional- and psychosis-related responses, including interactions between this system with cholinergic, dopaminergic or glutamatergic systems.
The involvement of excitatory amino acids and peptides (opioid and anti-opioid) in drug dependence and pain. The research covers the following issues:
- the role of glutamate and its receptors (ionotropic and metabotropic) and inhibitors of the re-uptake in the addictive action of psychoactive substances,
- the role of glutamatergic neurotransmission in memory dysfunction induced by substances of abuse,
- the role of metabotropic glutamate receptor subtype 7 (mGluR7) in addictions to psychoactive substances,
- pharmacological evaluation of the activity of opioid peptides analogs (enkephalins and deltorphin) in pain and drug addiction,
- the role of the kiss-peptides in addictions to psychoactive substances and in pain,
- the effect of inhibitors of acetylcholinesterase on the activity of psychoactive substances.
- Participation of glutamatergic and L-arginine:NO:cGMP pathway in the central effects (tolerance, amnesia) of the benzodiazepines.
- The search for novel therapeutics, particularly in the areas of CNS disorders, as well as study of the mechanisms underlying and pharmacological examination of a new agents with affinity for serotonin family receptors.
- The study on morphine dependence: role of environmental factors (prenatal exposure for lead and fluorine), role of neuroinflammation. The significance of adenosinergic system in various aspect of morphine addiction.
Behavioural methods used at our Department:
- The locomotor activity test.
- Antinocieptive tests – the writhing test, the hot plate test, the tail-flick test.
- Motor coordination tests - the rota rod and chimney tests.
- Anxiety-related test – the elevated plus-maze test ,the open field test, the light-dark test.
- Memory-related tests – the modified elevated plus-maze test; the novel object recognition test, Barnes’ test, the passive avoidance test.
- The conditioned place preference test.
- Antidepressant activity – the Porsolt’s test and tail suspension test.
- Anti-epileptic activity – pentylenetetrazole-induced seizures test in mice and rats, electroshock in mice.
- INSERM U952 in Paris, France.
- Department of Medical Education, California Northstate University College of Medicine, Elk Grove, CA, USA.
- Department of Biomedical Sciences, Section of Microbiology and Virology, University of Cagliary, Italy.
- School of Pharmacy, Faculty of Health Sciences University of Eastern Finland, Kuopio, Finlandia.
- Department of Medicinal Chemistry, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
- Department of Biochemistry and Neurobiology, AGH University of Science and Technology in Cracow, Poland.
- Department of Neurochemistry, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland.
- Peptides Laboratory of the Faculty of Chemistry of Warsaw University, Poland.
- Chair and Department of Biochemistry, Medical University of Warsaw, Poland.
- Department of Pharmacogenomics, Faculty of Pharmacy, Medical University of Warsaw, Poland.
- Department of Physiology, Pomeranian Medical University, Szczecin, Poland.
- Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Szczecin, Poland.
- Department of Biopharmacy, Medical University of Lublin, Poland.
- Chair and Department of Synthesis and Chemical Technology of Pharmaceutical Substances, Medical University of Lublin, Poland.
- Chair and Department of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, Poland.
- Chair and Department of Medical Chemistry, Medical University of Lublin, Poland.
- Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
Grant no. NCN: 2013/09/D/NZ7/04549 "The influence of allosteric modulation of nicotinic receptors on the risk of cognitive impairment in humans", investigators: prof. Grażyna Biała, dr Marta Kruk-Słomka.
Grant no. NCN 2013/11/B/NZ7/04837 "Behavioral and biochemical evaluation of mephedrone's action and interaction with other psychoactive drugs”, principle investigator: prof. Grażyna Biała, investigator: dr Barbara Budzyńska.
Grant No. NCN: 2014/13/B/NZ4/01249 “Influence of the chemical structure of coumarins derivatives on their central effects evaluated in behavioral and biochemical studies”, principle investigator: dr Barbara Budzyńska, investigators prof. Grażyna Biała, dr Marta Kruk-Słomka.
Grant No. NN405 161639 - from the Polish National Science Centre: "The impact of deltorphin and enkephalin analogs on the perception of pain and motivational aspects of dependency on psychoactive substances" (2010-2013); principle investigator: prof. dr hab. Jolanta Kotlińska; investigator: mgr farm. Ewa Gibuła-Bruzda.
Higher Education Research Grant, Poland No. 3048/B/H03/2009/37: "Identification of bioactive kryptein in the central nervous system" (2009-2012); investigator: prof. dr hab. Jolanta Kotlińska.
International grant sponsored by the International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy, No. CRP / POL05-02: "Proteome in the Central Nervous System in Drug Dependence" (2006-2009); investigator: prof. dr hab. Jolanta Kotlińska.
Grant No. 3744 / B / H03 / 2011/40 from the Polish National Science Centre: "Local distribution and response system for the administration of brain peptide ICV selected drugs. Research DESI-MS technique "(2011-2014); investigator: prof. dr hab. Jolanta Kotlińska.
The project of European funds, financed by the National Centre for Research and Development Consortium of German-French-Polish No. 05/ EuroNanoMed/2012: "The application of aptamers in metastatic prostate cancer – the nucleic acids in targeted therapy and diagnostics" (2012-2016); investigator: prof. dr hab. Jolanta Kotlińska.
International grant nr 6169.I/2005/2006 of the Integrated Action Program „Polonium” and bilateral french-polish cooperation attributed by the Polish Ministry of the Higher Education, Department of International Cooperation and by the French Ministry of Foreign Affairs together with the Ministry of National Education. Subject: “Physiological role of organic cation transporters in monoaminergic transmission in the central nervous system”; supervisor: prof. dr hab. Grażyna Biała.
Project of the UE; PO KL Operation 9.4: European Social Fund, Human Capital, National Cohesion Strategy: „Safety education – training in first aid and diagnosis of substance abuse. The highly qualified staff of the education system”. Main executors: prof, dr hab. Grażyna Biała.
Kinga Gawel, MSc. (our doctoral student in years 2011-2015; her supervisor – prof. J. Kotlinska) has been staying in Sweden till April 2016, at the Uppsala University as she received financial support from the National Science Center, Poland, for preparation of her doctoral thesis within a framework of doctoral scholarship based on the decision DEC-2015/16/T/NZ7/00171.